Parainfluenza Virus Surface Projections: Glycoproteins with Haemagglutinin and Neuraminidase Activities
نویسندگان
چکیده
منابع مشابه
Efficacy of the novel parainfluenza virus haemagglutinin-neuraminidase inhibitor BCX 2798 in mice - further evaluation.
BACKGROUND Human parainfluenza virus type 1 (hPIV-1) causes serious respiratory tract infections, especially in children. This study investigated the efficacy of the novel haemagglutinin-neuraminidase (HN) inhibitor BCX 2798 in the prophylaxis of lethal and the treatment of non-lethal parainfluenza virus infection in mice. METHODS In the prophylaxis model, 129x1/SvJ mice were inoculated with ...
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The sequence variation in a 934 base-pair region of the gene encoding the haemagglutinin-neuraminidase of five human parainfluenza virus type 3 (HPIV3) isolates was determined together with that of a prototype UK strain. All of the clinical isolates were from the Manchester area of the UK and were obtained in 1990, 1991 and 1993. The gene segment was amplified by the polymerase chain reaction u...
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A vaccine was prepared containing the haemagglutirain and neuraminidase subunits from the A/Port Chalmers. 1/73 (H3N2) strain of influenza virus. The virus particles were disrupted with ammonium deoxycholate and the matrix protein, which was insoluble in this detergent, was removed by centrifugation. Following removal of deoxycholate, the haemagglutinin and neuraminidase subunits aggregated by ...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 1971
ISSN: 0022-1317,1465-2099
DOI: 10.1099/0022-1317-11-1-53